{"id":591,"date":"2023-12-01T21:13:59","date_gmt":"2023-12-01T13:13:59","guid":{"rendered":"https:\/\/www.mfzx.org.cn\/?p=591"},"modified":"2023-12-01T21:13:59","modified_gmt":"2023-12-01T13:13:59","slug":"%e9%a9%ac%e5%87%a1%e7%bb%bc%e5%90%88%e5%be%81%e7%9a%84%e9%81%97%e4%bc%a0%e5%ad%a6%e9%97%ae%e9%a2%98","status":"publish","type":"post","link":"http:\/\/www.mfzx.org.cn\/?p=591","title":{"rendered":"\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u9057\u4f20\u5b66\u95ee\u9898"},"content":{"rendered":"<p style=\"text-align: center\">\u8c2d\u8dc3\u7403\uff1a\u7814\u7a76\u5458 \u4e2d\u4fe1\u6e58\u96c5\u751f\u6b96\u4e0e\u9057\u4f20\u4e13\u79d1\u533b\u9662<\/p>\n<p><strong>1<\/strong><strong>\u3001\u9a6c\u51e1\u7efc\u5408\u5f81\u662f\u4e00\u79cd\u201c\u5929\u624d\u75c5\u201d<\/strong><\/p>\n<p>\u9a6c\u51e1\u7efc\u5408\u5f81\uff08Marfan syndrome, MFS\uff09\u7531\u6cd5\u56fd\u513f\u79d1\u533b\u751fMarfan 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loading=\"lazy\" decoding=\"async\" class=\" wp-image-592 aligncenter\" src=\"https:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74031-265x300.png\" alt=\"\" width=\"337\" height=\"382\" srcset=\"http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74031-265x300.png 265w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74031.png 617w\" sizes=\"auto, (max-width: 337px) 100vw, 337px\" \/><\/p>\n<p style=\"text-align: center\">\u56fe1-1 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loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-596 aligncenter\" src=\"https:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74032-300x235.jpg\" alt=\"\" width=\"333\" height=\"261\" srcset=\"http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74032-300x235.jpg 300w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74032-768x601.jpg 768w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74032.jpg 832w\" sizes=\"auto, (max-width: 333px) 100vw, 333px\" \/><\/p>\n<p style=\"text-align: center\">\u56fe2-1 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loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-594 aligncenter\" src=\"https:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74033-300x300.jpg\" alt=\"\" width=\"387\" height=\"387\" srcset=\"http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74033-300x300.jpg 300w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74033-150x150.jpg 150w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74033.jpg 600w\" sizes=\"auto, (max-width: 387px) 100vw, 387px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center\">\u56fe2-2 \u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u56fe\u89e3<\/p>\n<p><strong>3<\/strong><strong>\u3001<\/strong><strong><em>FBN1<\/em><\/strong><strong>\u57fa\u56e0\u4e3a\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u81f4\u75c5\u57fa\u56e0<\/strong><\/p>\n<p>\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u81f4\u75c5\u57fa\u56e0\u4e3a\u5b9a\u4f4d\u4e8e15\u53f7\u67d3\u8272\u4f532\u533a1\u5e26\uff0815q21\uff09\u7684\u539f\u7ea4\u86cb\u767d1\u57fa\u56e0\uff08<strong><em>FBN1<\/em><\/strong>\uff09\uff0c\u4eba\u7c7b\u5728\u7ebf\u5b5f\u5fb7\u5c14\u9057\u4f20\u7684\u7f16\u53f7\u4e3a134797 \uff08OMIM 134797\uff09\u3002<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u5168\u957f\u7ea6237kb(\u5343\u78b1\u57fa\u5bf9)\uff0c\u5305\u542b66\u4e2a\u5916\u663e\u5b50\uff08\u57fa\u56e0\u4e2d\u7f16\u7801\u6c28\u57fa\u9178\u7684\u5e8f\u5217\u79f0\u4e3a\u5916\u663e\u5b50\uff09\uff0c\u7f16\u78012871\u4e2a\u6c28\u57fa\u9178\u3002\u539f\u7ea4\u86cb\u767d\u9664\u4e86\u5bf9\u4e00\u4e9b\u7ec4\u7ec7\u8d77\u56fa\u4f4d\u4f5c\u7528\u5916\uff0c\u8fd8\u5728\u5f39\u6027\u86cb\u767d\u7684\u524d\u4f53\u4e0e\u5f39\u6027\u7ea4\u7ef4\u5f62\u6210\u7684\u8fc7\u7a0b\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u5e7f\u6cdb\u5206\u5e03\u4e8e\u4eba\u4f53\u7684\u4e3b\u52a8\u8109\u3001\u773c\u6676\u72b6\u4f53\u53ca\u9aa8\u819c\u4e2d\u3002\u6839\u636e\u539f\u7ea4\u86cb\u767d\u7684\u529f\u80fd\u548c\u5206\u5e03\u60c5\u51b5\uff0c\u6211\u4eec\u5c31\u5f88\u5bb9\u6613\u7406\u89e3\u4e3a\u4ec0\u4e48\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u5e38\u5e38\u4f1a\u7d2f\u53ca\u9aa8\u9abc\u3001\u773c\u775b\u548c\u5fc3\u8840\u7ba1\u7cfb\u7edf\u3002<\/p>\n<p>\u6839\u636e\u4eba\u7c7b\u57fa\u56e0\u7a81\u53d8\u6570\u636e\u5e93(HGMD)\u8bb0\u8f7d\uff0c\u76ee\u524d\u5728\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u4e2d\u9274\u5b9a\u4e86\u7ea63000\u4e2a<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u81f4\u75c5\u7a81\u53d8\uff0c\u5305\u62ec\u9519\u4e49\u7a81\u53d8\uff08\u7a81\u53d8\u540e\u7531\u4e00\u4e2a\u6c28\u57fa\u9178\u53d8\u6210\u53e6\u5916\u4e00\u4e2a\u6c28\u57fa\u9178\uff09\u3001\u65e0\u4e49\u7a81\u53d8\uff08\u7a81\u53d8\u540e\u7531\u4e00\u4e2a\u6c28\u57fa\u9178\u53d8\u6210\u6c28\u57fa\u9178\u7ec8\u6b62\u5bc6\u7801\u5b50\uff09\u3001\u79fb\u7801\u7a81\u53d8\uff08\u7a81\u53d8\u540e\u5bfc\u81f4\u57fa\u56e0\u7684\u9605\u8bfb\u6846\u6539\u53d8\uff09\u3001\u526a\u5207\u4f4d\u70b9\u7a81\u53d8\uff08\u7a81\u53d8\u4f4d\u4e8e\u526a\u5207\u4f4d\u70b9\u9644\u8fd1\uff09\u3001\u5c0f\u7684\u7f3a\u5931\u548c\u63d2\u5165\uff08\u7f3a\u5931\u548c\u63d2\u5165\u7684\u78b1\u57fa&lt;50bp\uff09\u53ca\u5916\u663e\u5b50\u548c\u6574\u4e2a\u57fa\u56e0\u7684\u91cd\u590d\/\u7f3a\u5931\u7b49\u3002<strong><em>FBN1<\/em><\/strong>\u7a81\u53d8\u9664\u4e86\u5bfc\u81f4\u9a6c\u51e1\u7efc\u5408\u5f81\u5916\uff0c\u8fd8\u53ef\u80fd\u4f1a\u5bfc\u81f4\u5176\u4ed6\u75be\u75c5\uff0c\u5982\u80a2\u7aef\u53d1\u80b2\u4e0d\u826f\u3001\u5355\u7eaf\u6027\u6676\u72b6\u4f53\u5f02\u4f4d\u548c\u4ec5\u6709\u8f7b\u5fae\u9aa8\u9abc\u5f02\u5e38\u7684\u5347\u4e3b\u52a8\u8109\u7624\u7b49\u3002\u8fd1\u5e74\u6765\uff0c\u4e5f\u6709\u5b66\u8005\u53d1\u73b0<strong><em>TGFBR1<\/em><\/strong>\u548c<strong><em>TGFBR2<\/em><\/strong>\u57fa\u56e0\u7a81\u53d8\u53ef\u80fd\u4e0e\u9a6c\u51e1\u7efc\u5408\u5f81\u76f8\u5173\u3002<\/p>\n<p><strong>4<\/strong><strong>\u3001\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u81f4\u75c5\u673a\u5236<\/strong><\/p>\n<p>\u539f\u7ea4\u7ef4\u86cb\u767d1(FBN1)\u662f\u4e00\u79cd\u7ec6\u80de\u5916\u57fa\u8d28\u86cb\u767d\uff0c\u4e3a\u5f39\u6027\u7ec4\u7ec7\u7684\u4e3b\u8981\u86cb\u767d\u7ec4\u5206\uff0c\u53c2\u4e0e\u4e86\u5f39\u6027\u57fa\u8d28\u7684\u5f62\u6210\u548c\u7a33\u6001\u3001\u57fa\u8d28\u4e0e\u7ec6\u80de\u95f4\u7684\u7c98\u9644\uff0c\u5728\u7ed3\u7f14\u7ec4\u7ec7\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u5982\u4e3b\u52a8\u8109\u3001\u9aa8\u819c\u548c\u6676\u72b6\u4f53\u7b49\u3002\u5f53<strong><em>FBN1<\/em><\/strong>\u4e00\u4e2a\u7b49\u4f4d\u57fa\u56e0\u53d1\u751f\u7a81\u53d8\u65f6\uff0c\u4ea7\u751f\u7684\u5f02\u5e38FBN1\u86cb\u767d\u4f1a\u5e72\u6270\u53e6\u4e00\u4e2a\u6b63\u5e38FBN1\u86cb\u767d\u7684\u529f\u80fd\uff0c\u5373\u4ea7\u751f\u4e86\u663e\u6027\u8d1f\u6548\u5e94\uff0c\u4ece\u800c\u5f71\u54cd\u539f\u7ea4\u7ef4\u86cb\u767d\u7684\u5f62\u6210\u3001\u7ec4\u88c5\u3001\u5206\u6ccc\u548c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u6c89\u7740\uff0c\u4ece\u800c\u7834\u574f\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u7ed3\u6784\uff0c\u4ea7\u751f\u76f8\u5bf9\u5e94\u7684\u4e34\u5e8a\u8868\u578b\u3002<\/p>\n<p><strong>5<\/strong><strong>\u3001\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u57fa\u56e0\u68c0\u6d4b<\/strong><\/p>\n<p>\u9488\u5bf9<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u6d4b\u5e8f\u662f\u9a6c\u51e1\u7efc\u5408\u5f81\u57fa\u56e0\u68c0\u6d4b\u7684\u9996\u9009\u65b9\u6cd5\u3002<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u7684\u7a81\u53d8\u7c7b\u578b\u4e3b\u8981\u5305\u62ec\u5916\u663e\u5b50\u53ca\u5176\u90bb\u8fd1\u5e8f\u5217\u7684\u70b9\u7a81\u53d8\u53ca\u5916\u663e\u5b50\u6216\u6574\u4e2a\u57fa\u56e0\u7684\u91cd\u590d\/\u7f3a\u5931\u7a81\u53d8\uff0c\u76ee\u524d<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u4e3b\u8981\u7684\u68c0\u6d4b\u65b9\u6cd5\u5305\u62ec\uff081\uff09\u76ee\u6807\u57fa\u56e0\u6355\u83b7\u540e\u8fdb\u884c\u7b2c\u4e8c\u4ee3\u6d4b\u5e8f(NGS\u6d4b\u5e8f)\uff0c\uff082\uff09Sanger\u6d4b\u5e8f\uff0c\uff083\uff09\u591a\u91cd\u94fe\u63a5\u63a2\u9488\u6269\u589e\u6280\u672f\uff08MLPA\uff09\u68c0\u6d4b\u3002<\/p>\n<p>\u76ee\u6807\u57fa\u56e0\u6355\u83b7\u540eNGS\u6d4b\u5e8f\u548cSanger\u6d4b\u5e8f\u53ef\u4ee5\u68c0\u51fa<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u5916\u663e\u5b50\u53ca\u5176\u90bb\u8fd1\u5e8f\u5217\u7684\u70b9\u7a81\u53d8\uff0c\u5305\u62ec\u65e0\u4e49\u7a81\u53d8\u3001\u9519\u4e49\u7a81\u53d8\u3001\u526a\u5207\u4f4d\u70b9\u7a81\u53d8\u53ca\u5c0f\u7684\u63d2\u5165\/\u7f3a\u5931\u7b49\u3002\u56e0<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u5916\u663e\u5b50\u8f83\u591a(66\u4e2a)\uff0c\u4e00\u822c\u4f7f\u7528NGS\u6d4b\u5e8f\u6280\u672f\u5bf9\u5bb6\u65cf\u4e2d\u5148\u8bc1\u8005\uff08\u9996\u5148\u4ece\u5bb6\u7cfb\u4e2d\u524d\u6765\u5c31\u8bca\u6216\u53d1\u73b0\u7684\u7b2c\u4e00\u4e2a\u60a3\u75c5\u4e2a\u4f53,\u79f0\u5148\u8bc1\u8005\uff09\u7684<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u6240\u6709\u5916\u663e\u5b50\u53ca\u5176\u90bb\u8fd1\u533a\u57df\u8fdb\u884c\u68c0\u6d4b\uff0c\u7136\u540e\u9488\u5bf9\u68c0\u6d4b\u5230\u7684\u7a81\u53d8\u4f7f\u7528Sanger\u6d4b\u5e8f\u6280\u672f\u5bf9\u5bb6\u5ead\u5176\u4ed6\u6210\u5458\u8fdb\u884c\u68c0\u6d4b\u3002MLPA\u6280\u672f\u53ef\u4ee5\u68c0\u51fa<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u5916\u663e\u5b50\u6216\u6574\u4e2a\u57fa\u56e0\u7684\u91cd\u590d\/\u7f3a\u5931\u7a81\u53d8\u3002<\/p>\n<p><strong>6<\/strong><strong>\u3001<\/strong><strong><em>FBN1<\/em><\/strong><strong>\u57fa\u56e0\u578b\u4e0e\u9a6c\u51e1\u7efc\u5408\u5f81\u8868\u578b\u7684\u76f8\u5173\u6027<\/strong><\/p>\n<p>\u76ee\u524d\u5c1a\u672a\u6709\u6587\u732e\u62a5\u9053\u5728\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u4e2d\u5b58\u5728\u57fa\u56e0\u578b\u4e0e\u8868\u578b\u4e4b\u95f4\u7684\u5173\u8054\u6027\u3002\u5373\u4f7f\u5728\u540c\u4e00\u5bb6\u5ead\u4e2d\uff0c\u643a\u5e26\u540c\u4e00\u4e2a<strong><em>FBN1<\/em><\/strong>\u81f4\u75c5\u7a81\u53d8\u7684\u4e0d\u540c\u60a3\u8005\u7684\u4e34\u5e8a\u8868\u73b0\u53ef\u80fd\u4f1a\u5b58\u5728\u8f83\u5927\u7684\u5dee\u5f02\u3002<\/p>\n<p><strong>7<\/strong><strong>\u3001\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u9884\u9632\u548c\u963b\u65ad<\/strong><\/p>\n<p>\u9a6c\u51e1\u7efc\u5408\u5f81\u4e3a\u5355\u57fa\u56e0\u9057\u4f20\u75c5\uff0c\u4e00\u822c\u4ece\u5a5a\u524d\u68c0\u67e5\u3001\u9057\u4f20\u54a8\u8be2\u3001\u5b55\u524d\u8bca\u65ad\u548c\u4ea7\u524d\u8bca\u65ad\u8fdb\u884c\u9884\u9632\u548c\u963b\u65ad\u3002<\/p>\n<p>7.1\u5a5a\u524d\u68c0\u67e5<\/p>\n<p>\u8be6\u7ec6\u8be2\u95ee\u7537\u5973\u53cc\u65b9\u53ca\u5176\u5bb6\u5ead\u6210\u5458\u7684\u5065\u5eb7\u72b6\u51b5\u3001\u65e2\u5f80\u75c5\u53f2\u53ca\u533b\u6cbb\u60c5\u51b5\uff0c\u5bf9\u6709\u8eab\u9ad8\u660e\u663e\u9ad8\u4e8e\u5e38\u4eba\u3001\u6676\u72b6\u4f53\u5f02\u4f4d\/\u8131\u843d\u3001\u5fc3\u810f\u75be\u75c5\u5bb6\u65cf\u53f2\u7684\uff0c\u5e94\u8fdb\u884c\u76f8\u5e94\u7684\u57fa\u56e0\u68c0\u67e5\uff0c\u68c0\u51fa\u60a3\u8005\u3002<\/p>\n<p>7.2\u9057\u4f20\u54a8\u8be2<\/p>\n<p>\u5982\u679c\u5bb6\u5ead\u4e2d\u6ca1\u6709\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\uff0c\u5219\u7f79\u60a3\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u98ce\u9669\u540c\u6b63\u5e38\u4eba\u7fa4\uff0c\u53d1\u75c5\u7387\u7ea6\u4e3a1:5,000-1:10,000\u3002\u5982\u679c\u5bb6\u5ead\u4e2d\u5b58\u5728\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\uff0c\u901a\u8fc7\u57fa\u56e0\u68c0\u67e5\uff0c\u660e\u786e\u4e86<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u7684\u81f4\u75c5\u7a81\u53d8\uff0c\u5176\u5bb6\u5ead\u6210\u5458\u60a3\u75c5\u98ce\u9669\u5982\u4e0b\uff1a<\/p>\n<ul>\n<li>\u5148\u8bc1\u8005\u7684\u7236\u6bcd<\/li>\n<li>3\/4\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u7684<strong><em>FBN1<\/em><\/strong>\u81f4\u75c5\u7a81\u53d8\u9057\u4f20\u81ea\u5176\u7f79\u60a3\u9a6c\u51e1\u7efc\u5408\u5f81\u7684\u7236\u6bcd\uff1b<\/li>\n<li>1\/4\u7684\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u662f\u7531\u4e8e<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u65b0\u53d1\u7a81\u53d8\u6240\u5bfc\u81f4\uff0c\u7236\u6bcd\u4e0d\u643a\u5e26<em>FBN1<\/em>\u57fa\u56e0\u81f4\u75c5\u7a81\u53d8\uff1b<\/li>\n<li>\u82e5\u5148\u8bc1\u8005\u4e2d\u5df2\u68c0\u51fa<strong><em>FBN1<\/em><\/strong>\u81f4\u75c5\u7a81\u53d8\uff0c\u5219\u53ef\u5bf9\u5176\u7236\u6bcd\u8fdb\u884c\u8be5\u4f4d\u70b9\u7684\u57fa\u56e0\u68c0\u6d4b\u3002<\/li>\n<li>\u82e5\u7236\u6bcd\u53cc\u65b9\u8840\u6db2DNA\u4e2d\u5747\u672a\u68c0\u51fa\u5148\u8bc1\u8005\u643a\u5e26\u7684<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u81f4\u75c5\u7a81\u53d8\uff0c\u53ef\u80fd\u662f\u56e0\u4e3a\u5148\u8bc1\u8005<strong><em>FBN1<\/em><\/strong>\u81f4\u75c5\u7a81\u53d8\u4e3a\u65b0\u53d1\u7a81\u53d8\uff0c\u6216\u8005\u5176\u7236\u6bcd\u4e3a\u751f\u6b96\u817a\u5d4c\u5408\u4f53\u3002<\/li>\n<\/ul>\n<p>\u6ce8\u610f\uff1a\u5c3d\u7ba13\/4\u7684\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u90fd\u6709\u9a6c\u51e1\u7efc\u5408\u5f81\u5bb6\u65cf\u53f2\uff0c\u4f46\u5b58\u5728\u7531\u4e8e\u60a3\u8005\u5728\u51fa\u73b0\u75c7\u72b6\u4e4b\u524d\u65e9\u671f\u6b7b\u4ea1\uff0c\u4f7f\u5f97\u672a\u80fd\u8bc6\u522b\u5bb6\u5ead\u6210\u5458\u7684\u75c5\u75c7\uff0c\u5bfc\u81f4\u9634\u6027\u7684\u5bb6\u65cf\u53f2\u3002<\/p>\n<p>\u5148\u8bc1\u8005\u7684\u540c\u80de<\/p>\n<p>\u5982\u679c\u5148\u8bc1\u8005\u7684\u7236\u6bcd\u643a\u5e26<strong><em>FBN1<\/em><\/strong>\u81f4\u75c5\u7a81\u53d8\uff0c\u5219\u5176\u540c\u80de\u4e0d\u60a3\u75c5\u7684\u98ce\u9669\u662f50%\uff0c\u60a3\u75c5\u98ce\u9669\u4e5f\u662f50%\u3002<\/p>\n<p>\u5982\u679c\u5148\u8bc1\u8005\u7236\u6bcd\u672a\u7f79\u60a3\u9a6c\u51e1\u7efc\u5408\u5f81\uff0c\u4e14\u672a\u68c0\u51fa<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u81f4\u75c5\u7a81\u53d8\uff0c\u90a3\u4e48\u5148\u8bc1\u8005\u540c\u80de\u60a3\u75c5\u98ce\u9669\u5f88\u4f4e\u3002\u4f46\u56e0\u4e0d\u80fd\u6392\u9664\u5176\u7236\u6bcd\u4e3a\u751f\u6b96\u817a\u5d4c\u5408\u4f53\u7684\u53ef\u80fd\uff0c\u5148\u8bc1\u8005\u540c\u80de\u60a3\u75c5\u98ce\u9669\u4ecd\u7136\u9ad8\u4e8e\u5065\u5eb7\u4eba\u7fa4\u3002<\/p>\n<p>\u5148\u8bc1\u8005\u540e\u4ee3<\/p>\n<p>\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\u7684\u5b69\u5b50\uff0c\u67091\/2\u7684\u6982\u7387\u9057\u4f20<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u81f4\u75c5\u7a81\u53d8\u4ece\u800c\u60a3\u75c5\u3002<\/p>\n<p>7.3\u80da\u80ce\u690d\u5165\u524d\u5355\u57fa\u56e0\u9057\u4f20\u5b66\u68c0\u6d4b(PGT-M) \u548c\u4ea7\u524d\u8bca\u65ad<\/p>\n<p>\u5982\u679c\u5bb6\u5ead\u4e2d\u5b58\u5728\u9a6c\u51e1\u7efc\u5408\u5f81\u60a3\u8005\uff0c\u901a\u8fc7\u57fa\u56e0\u8bca\u65ad\u660e\u786e\u4e86<strong><em>FBN1<\/em><\/strong>\u57fa\u56e0\u7684\u81f4\u75c5\u7a81\u53d8\uff0c\u5219\u53ef\u4ee5\u901a\u8fc7\u80da\u80ce\u690d\u5165\u524d\u9057\u4f20\u5b66\u68c0\u6d4b(PGT-M) \u6216\u4ea7\u524d\u8bca\u65ad\u9632\u6b62\u60a3\u513f\u7684\u51fa\u751f\u3002<\/p>\n<p>\u80da\u80ce\u690d\u5165\u524d\u5355\u57fa\u56e0\u75c5\u9057\u4f20\u5b66\u68c0\u6d4b\uff08PGT-M\uff09\uff1a\u4e5f\u53eb\u201c\u7b2c\u4e09\u4ee3\u8bd5\u7ba1\u5a74\u513f\u201d\uff0c\u8be5\u6280\u672f\u662f\u5efa\u7acb\u5728\u4f53\u5916\u57f9\u517b-\u80da\u80ce\u79fb\u690d\u6280\u672f\uff08\u4fd7\u79f0\u201c\u8bd5\u7ba1\u5a74\u513f\u201d\uff09\u7684\u57fa\u7840\u4e0a\u3002\u5177\u4f53\u6d41\u7a0b\u662f\u5728\u80da\u80ce\u53d1\u80b2\u5230\u5375\u88c2\u7403\u671f\u6216\u56ca\u80da\u671f\u6d3b\u68c03-5\u4e2a\u7ec6\u80de\u8fdb\u884c\u9057\u4f20\u5b66\u68c0\u6d4b\uff0c\u660e\u786e\u88ab\u68c0\u6d4b\u80da\u80ce\u662f\u5426\u5b58\u5728\u5148\u8bc1\u8005\u643a\u5e26\u7684<strong><em>FBN1<\/em><\/strong>\u81f4\u75c5\u7a81\u53d8\uff0c\u7136\u540e\u9009\u62e9\u6b63\u5e38\u7684\u80da\u80ce\u8fdb\u884c\u79fb\u690d\uff0c\u4ece\u800c\u907f\u514d\u56e0\u6000\u4e0a\u60a3\u513f\u9700\u8fdb\u884c\u4eba\u5de5\u6d41\u4ea7\u7684\u98ce\u9669\u3002\u4e3b\u8981\u7684\u6d41\u7a0b\u5305\u62ec\u6388\u7cbe\u3001\u80da\u80ce\u57f9\u517b\u3001\u80da\u80ce\u6d3b\u68c0\u3001\u6269\u589e\u3001\u57fa\u56e0\u68c0\u6d4b\u3001\u7ed3\u679c\u5206\u6790\uff08\u56fe7-1\uff09\uff0c\u6700\u540e\u9009\u62e9\u6b63\u5e38\u7684\u80da\u80ce\u8fdb\u884c\u79fb\u690d\u3002<img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-597 aligncenter\" src=\"https:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74034-300x169.jpg\" alt=\"\" width=\"604\" height=\"340\" srcset=\"http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74034-300x169.jpg 300w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74034-1024x576.jpg 1024w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74034-768x432.jpg 768w, http:\/\/www.mfzx.org.cn\/wp-content\/uploads\/2023\/12\/\u624b\u518c-\u8c2d\u8dc3\u74034.jpg 1268w\" sizes=\"auto, (max-width: 604px) 100vw, 604px\" \/>\u56fe7-1\u00a0 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[&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-591","post","type-post","status-publish","format-standard","hentry","category-pregnant"],"_links":{"self":[{"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=591"}],"version-history":[{"count":1,"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/591\/revisions"}],"predecessor-version":[{"id":598,"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=\/wp\/v2\/posts\/591\/revisions\/598"}],"wp:attachment":[{"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=591"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.mfzx.org.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}